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HelpTest Code DLAC D-Lactate, Plasma
Reporting Name
D-Lactate, PUseful For
As an adjunct to urine D-lactate (preferred) for the diagnosis of D-lactate acidosis
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Plasma NaFl-KOxOrdering Guidance
Urine is the preferred specimen for D-lactate determination, order DLAU / D-Lactate, Urine.
For determination of L-lactate (lactic acid), order LACS1 / Lactate, Plasma
Specimen Required
Supplies: Sodium Fluoride/Potassium Oxalate Tube, 2 mL (T275)
Collection Container/Tube:
Preferred: Sodium fluoride/potassium oxalate tube
Acceptable: Green top (sodium heparin)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge, aliquot plasma into a plastic vial, and freeze immediately.
NOTE: If collecting in sodium heparin tubes, centrifugation must occur within one hour of collection.
Specimen Minimum Volume
0.15 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma NaFl-KOx | Frozen (preferred) | 91 days | |
| Ambient | 91 days | ||
| Refrigerated | 91 days |
Day(s) Performed
Monday, Thursday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83605
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DLAC | D-Lactate, P | 14045-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8878 | D-Lactate, P | 14045-9 |
Clinical Information
D-lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. When large amounts of D-lactate are present, individuals can experience metabolic acidosis, altered mental status (from drowsiness to coma), and a variety of other neurologic symptoms, in particular dysarthria and ataxia. Although a temporal relationship has been described between elevations of plasma and urine D-lactate and the accompanying encephalopathy, the mechanism of neurologic manifestations has not been elucidated.
D-lactic acidosis is typically observed in patients with a malabsorptive disorder, such as short-bowel syndrome, or following a jejunoileal bypass. In addition, healthy children presenting with gastroenteritis may also develop the clinical presentation of D-lactic acidosis.
Routine lactic acid determinations in blood will not reveal abnormalities because most lactic acid assays measure only L-lactate. Accordingly, D-lactate analysis must be specifically requested (eg, this test). However, as D-lactate is readily excreted in urine, it is the preferred specimen for D-lactate determinations; see DLAU / D-Lactate, Urine.
Cautions
The test performed is for D-lactate. This is a product of bacterial overgrowth in the gastrointestinal tract. It should not be confused with L-lactate, which accumulates in some metabolic acidosis.
Report Available
3 to 6 daysSpecimen Retention Time
1 monthReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Gas Chromatography Mass Spectrometry (GCMS) Stable Isotope Dilution Analysis